Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy
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چکیده
منابع مشابه
Correction: Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy
[This corrects the article DOI: 10.1371/journal.pone.0163722.].
متن کاملRandomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy
BACKGROUND To help decide when to start and when to stop pre-emptive therapy for cytomegalovirus infection, we conducted two open-label randomized controlled trials in renal, liver and bone marrow transplant recipients in a single centre where pre-emptive therapy is indicated if viraemia exceeds 3000 genomes/ml (2520 IU/ml) of whole blood. METHODS Patients with two consecutive viraemia episod...
متن کاملPre-emptive treatment of Cytomegalovirus
Valganciclovir is equally efficacious in preventing CMV disease when used as prophylaxis or as pre-emptive treatment (Level 2 evidence but not designed for this outcome) Pre-emptive treatment of CMV infection results in significantly less leukopenia than prophylaxis, however, there is no difference in other adverse events. Pre-emptive treatment with 1⁄2 dose ganciclovir and 1⁄2 dose foscarnet r...
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BACKGROUND Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there is a lack of data for pre-emptive therapy in patients with HIV/AIDS. METHOD This was a retrospective study, which enrolled patients diagnosed with HIV/AIDS (CD4<200 cells/μl), who had detectable CMV viral load (VL) during their stay in an adult medical intensive care unit...
متن کاملBlindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0163722